The hospital at Grunwaldzka Street in Poznań, located in the building of the former Hotel Polonia, has a rich history dating back to World War II, when it was transformed into a Luftwaffe Lazaret. After the war, it operated as a military hospital under the Ministry of National Defense, and since 2011, it has been the Karol Marcinkowski University of Medical Sciences Specialist Clinical Hospital in Poznań. Architecturally, the building from 1927 stands out with its spacious interiors, adapted to various medical needs, including surgical and internal medicine departments, as well as modern laboratories. During the war, the hospital played a key role in aiding wounded soldiers, contributing to its significance in the history of military medicine in Poland. Interestingly, during the Poznań June of 1956, the hospital admitted many victims of the protests, highlighting its role in historical events. Over the following decades, the institution evolved, adapting to the needs of modern medicine, expanding its range of services, and modernizing its infrastructure. In 2013, due to financial reasons, the hospital was merged with the Heliodor Święcicki Clinical Hospital, and plans are underway to relocate all departments to a new complex by 2025, reflecting contemporary challenges related to the transformation of the healthcare system in Poland. The hospital at Grunwaldzka remains a symbol of continuous evolution and adaptation in the field of medicine, serving as an important reference point in the history of Poznań.